Replicel releases safety, efficacy data on RCH-01 DSCC regenerative cell therapy for baldness, thinning hair.

According to data released by Replicel on March 14, 2017, "The five-year trial data set has confirmed the complete safety profile of a high-dose of dermal sheath cup cells (DSCC) for patients with pattern baldness due to androgenetic alopecia." 

DSCC therapy is the keystone technology for Replicel's RCH-01 product. Replicel reports that the first-in-human data on long-term safety endpoints for RCH-01 successfully met it's endpoints as they move forward toward further research, development and commercialization of the hair loss product in collaboration with Japanese company Shiseido. 

According to Replicel, histological examination of the injection sites via biopsies at 6, 12, 24 and 60 months after treatment on 19 patients revealed no significant pathology (tumor, granuloma, foreign body formation, etc.)  

 

 

In addition, efficacy data--while not statistically significant--revealed that there was a overall stabilization of hair loss in all participants as well as up to a 21% improvement in hair density in a top tier responder (average 4.2% increase in hair density overall). 

Replicel Chief Scientific Officer, Dr. Kevin McElwee, alluded to further research focusing on designing optimal cell number (dosage) and injection frequency (timing) to optimize peak efficacy in terms of increased hair density.  From his statements, it appears that smaller cell doses and more frequent treatment sessions may be used to achieve a superior effect in terms of increasing hair regrowth. 

“In summary,” stated RepliCel’s President and CEO, R. Lee Buckler, “we are very pleased with the results of this first-in-human study and are excited to move this product forward into the next phases of development.”

At Bauman Medical in Boca Raton, FL we are actively watching this--and other--continuing research in the field of cell therapy for hair regrowth in androgenetic alopecia (pattern baldness in men and women).  We are hoping to see the hair measurements of the hair regrowth performed with the HairCheck device which can be used to measure results from hair loss treatments such as PRP with Extracellular Matrix, SVF, MSCs, adipose stem cells or other cell therapy, compounded Formula 82M minoxidil, topical finasteride, laser therapy, hair transplantation and more. 

 

 


Aclaris JAK inhibitor research for baldness ATI-5001, ATI-5002, ATI-5003 is progressing

Aclaris JAK inhibitor DrAlanBauman

ACLARIS Therapeutics JAK Inhibitor Research on Androgenetic Alopecia, male and female pattern baldness is progressing

Below you will find an excerpt from an Edited Transcript of Aclaris Therapeutics Inc earnings conference call or presentation Thursday, November 3, 2016 at 12:30:00pm GMT:

I will now turn the call over to Dr. Stuart Shanler to give a brief update on the JAK inhibitor program in alopecia areata, vitiligo and androgenetic alopecia. Stu?

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Stuart Shanler, Aclaris Therapeutics, Inc. - Chief Scientific Officer [4]

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Thanks, Neal. Our JAK program continues to progress as expected with ATI-5001 for oral administration for the treatment of the most severe forms of alopecia areata -- that's alopecia totalis and alopecia universalis -- and ATI-5002 for topical administration, primarily for the patchy forms of alopecia areata.

We are pleased to report that the IND application for ATI-5001 has been submitted to the FDA, and we expect to begin a human pharmacokinetic/pharmacodynamic -- that's a PK/PD study -- before the end of this year, which is slightly ahead of schedule. For the topical version, the ATI-5002, we are on track to submit an IND application and begin a clinical trial in the first half of 2017, which is consistent with our previous guidance.

In addition to progressing our JAK treatment program for the treatment of alopecia areata and as we reported on our last call, we have initiated preclinical development of additional JAK inhibitors which we are developing for topical use both in vitiligo and androgenetic alopecia, which is also known as male or female pattern baldness. The program includes the development of ATI-5003, which is a covalently binding JAK3-specific inhibitor, and the preclinical and formulation work continue to progress as expected.

At Bauman Medical Group Hair Transplant and Hair Loss Treatment Center in Boca Raton, FL we will be keeping a close eye on this groundbreaking hair loss research as it progresses. 


Japanese Scientists Grow Hair Follicles in Mice from Bioengineered Skin using iPS Stem Cells

Ips stem cell hair growth mice engineered skin

Photo: Hair is seen growing out of skin cells derived from iPS cells and grafted onto the belly of a mouse. | Riken / kyodo

Japanese scientists said Saturday they have bioengineered the skin organ known as the integumentary system in mice using induced pluripotent stem (iPS) cells.

The achievement is likely to lead to further progress in regenerative medicine to treat severe burns, skin diseases and hair loss as the organ contains all the layers of skin tissues and appendages, such as hair follicles and sebaceous glands.

The group, made up of members from the Riken research institute, Tokyo University of Science, Kitasato University, Organ Technologies Inc. and others, cultured iPS cells from mice in vitro for one week and observed the formation of embryoid bodies with epithelial and mesenchymal cells. Next, the team, led by Riken’s Takashi Tsuji, transplanted some 30 such bodies with collagen gel in live mice.

Somewhat similar to the work that's been done at Sanford Burnham in California, Japanese scientists have grown hair follicles from bioengineered skin cells using iPS (induced pluripotent stem cells) in mice. Although there is a long way to go to achieve "unlimited" hair for humans, these research breakthroughs the beginning of stem cell hair loss "cures" which may be helpful for those suffering from various forms of alopecia. Male and female hair loss sufferers often lose self-esteem and self-confidence as coverage of the scalp diminishes due to hereditary (androgenetic alopecia) and other baldness conditions.

At Bauman Medical, we watch these stem cell hair growth breakthroughs with great anticipation and excitement and are looking forward to the day that this kind of therapy will be available for our hair loss patients!  Sincerely, Alan J. Bauman, M.D.  -  Diplomate, American Board of Hair Restoration Surgery

 

 


Male Pattern Baldness Linked to Colon Cancer

This is a reprint of a MedicalResearch.com Interview with:
Dr. Nana Keum, PhD
Department of Nutrition
Harvard T.H. Chan School of Public Health
Boston, MA

Medical Research: What is the background for this study? What are the main findings?

Dr. Keum: Male pattern baldness, the most common type of hair loss in men, is positively associated with androgens as well as IGF-1 and insulin, all of which are implicated in pathogenesis of colorectal neoplasia.  Therefore, it is biologically plausible that male pattern baldness, as a marker of underlying aberration in the regulation of the aforementioned hormones, may be associated with colorectal neoplasia.  In our study that examined the relationship between five male hair pattern at age 45 years (no-baldness, frontal-only-baldness, frontal-plus-mild-vertex-baldness, frontal-plus-moderate-vertex-baldness, and frontal-plus-severe-vertex-baldness) and the risk of colorectal adenoma and cancer, we found that frontal-only-baldness and frontal-plus-mild-vertex-baldness were associated with approximately 30% increased risk of colon cancer relative to no-baldness.  Frontal-only-baldness was also positively associated with colorectal adenoma.

 

Medical Research: What should clinicians and patients take away from your report?

Dr. Keum: While the relationship between male pattern baldness and prostate cancer risk has been widely examined, to our knowledge, this study represents the first to report a potential relationship between male pattern baldness and the risk of colorectal neoplasia.  Thus, our findings should be confirmed in other studies before making definite clinical recommendations.  Yet, in the meantime, it may be prudent for males with frontal-only-baldness or frontal-plus-mild-vertex-baldness at age 45 years, although their elevated risk is modest, to consult physicians about colonoscopy screening guidelines.

Medical Research: What recommendations do you have for future research as a result of this study?

Dr. Keum: To better understand etiologic mechanism linking male pattern baldness to colorectal neoplasia, future studies are warranted to examine the association of sex hormones, IGFs, and insulin in relation to subtypes of male pattern baldness.

Citation:

Br J Cancer. 2016 Jan 12;114(1):110-7. doi: 10.1038/bjc.2015.438.

Male pattern baldness and risk of colorectal neoplasia.

Keum N1,2, Cao Y1,2, Lee DH1,2, Park SM3, Rosner B4, Fuchs CS5, Wu K1, Giovannucci EL1

 

Hair is often an important outward sign of internal health and hair loss conditions are often associated, exacerbated or triggered by medical conditions. In this recent study we see the first published correlation between subtypes of hereditary male pattern baldness and the appearance of and increased risk of neoplastic colon polyps or colon cancer. --Dr. Alan Bauman

 


Is shedding normal after PRP Hair Regrowth treatment?

Shed_hairIs shedding normal after PRP Platelet Rich Plasma Hair Regrowth treatment using Bio-D?

In a word, YES.  Because of the natural cycling of hair follicles (on and off, essentially) when you stimulate the hair follicle using a strong hair regrowth treatment like PRP, LaserCap laser therapy, compounded minoxidil 82M, etc. it is common to see a short term shedding phase.  

How long does shedding last after PRP+BioD treatment? This shedding should last 8-10 weeks on average. 

Shedding can often be concerning for those experiencing hair loss and it is common for patients to call or email their hair doctor or HairCoach during this time describing shedding amounts that are more than double their normal rate per day.  

The good news is that when you compare treatment zone HMI (Hair Mass Index) measured with the HairCheck Trichometer at 90 days after the treatment and compare those with the baseline measurements done prior to the treatment, you will nearly ALWAYS see some significant improvement... provided you had PRP with BioD or ACell.

Hair growth improvements as measured with HMI in the treatment area will typically continue to improve for about 9-12 months with PRP+BioD and the plateau may last up to two years. [Bauman AJ - Novel Use of Cryopreserved Amniotic Tissue with PRP for Hair Regrowth - ISHRS Scientific Meeting Chicago Sep 201]  Visually, the area will begin to improve in about 6 months and full results from the treatment will be seen at around 12 months. 

Here is my old blog post regarding strong hair regrowth treatments and temporary shedding due to stimulated hair follicle cycling:

Shedding on Minoxidil, Propecia/Finasteride or Laser Therapy

Are you seeing excessive shedding after just beginning hair loss treatment with minoxidil (formula 82m or rogaine), laser therapy (lasercap or other)?   You might be having the "Dread Shed!"  But don't worry, keep up with the treatment... here's why:

Keep in mind that any regimen (medication or laser therapy) that stimulates follicles to switch into a growth phase can cause shedding. Because all hair follicles cycle-on and cycle-off over the course of your life, shedding is a VERY poor barometer for the measurement of hair loss or hair growth. Regardless of treatment, the more hair follicles you have, the more shedding you will have. "Resting" follicles may still contain a hair-shaft. When you apply minoxidil, for example, and the follicle "switches on" and the newly growing hair pushes out the old, resting hairshaft. The result: a shed. It is my feeling that any hair that is shed from starting a particular therapy wasn't in an anagen/growth phase anyway.

Remember that minoxidil/rogaine is a proven 'anagen-stimulator' which shifts restingfollicles into growing follicles. Female pattern hair loss (androgenetic alopecia) is characterized by miniaturizing follicles and a shortening of the natural growth-phases of the follicles.

Shedding when starting minoxidil, laser, or propecia (if it is noticeable) typically occurs within the first two to eight weeks of therapy. Keep in mind that it normally takes 10-20 weeks for microscopic hair density to peak with minoxidil AND six to twelve months to see visible results of the growth with minoxidil.

For questions on best hair regrowth treatments including hair transplants, visit Bauman Medical and Ask Dr. Bauman a Question.

Find a HairCoach near you. 

 

 

   


FDA-approved arthritis drug Tofacitinib grows full head of hair on a Alopecia patient

Zeljanz-tofacitinib-baldness-cure-arthritis-DrAlanBauman

Amazing discovery! FDA-approved arthritis drug, tofacitinib, grows a full head of hair on a patient suffering from Alopecia Universalis during a study at Yale.

http://boston.cbslocal.com/2014/06/19/hairless-man-grows-full-head-of-hair-in-yale-arthritis-drug-trial/

BOSTON (CBS) – Scientists at Yale may have discovered quite the off-label use for an FDA-approved arthritis drug.

During a trial which stretched for eight months, a 25-year-old man with almost no hair on his body grew a full head following treatment with the drug. He reported no noticeable side effects.

The patient was suffering from a rare, highly visible disease known as alopecia universalis, which has no cure or approved long term treatment.

The disease causes the loss of almost all body hair.

According to scientists involved in the trial, the patient also grew eyebrows, eyelashes, and facial, armpit, and other hair.

“The results are exactly what we hoped for,” said Brett A. King, M.D., assistant professor of dermatology at Yale University School of Medicine and senior author of a paper reporting the results online June 18 in the Journal of Investigative Dermatology. “This is a huge step forward in the treatment of patients with this condition. While it’s one case, we anticipated the successful treatment of this man based on our current understanding of the disease and the drug. We believe the same results will be duplicated in other patients, and we plan to try.”

The drug, called tofacitinib citrate has also been used successfully for treating psoriasis...

 

It will be interesting to see if this result can be duplicated in other patients suffering from Alopecia Univeralis! -Dr Bauman


Link between smoking and baldness gives you another reason to quit

It's been 50 years since the U.S. Surgeon General warned about the health risks of smoking, cutting smoking rates in half.  As some smokers still light up, do they realize the impact on hair, hair loss and baldness?

Male pattern baldness or Androgenetic Alopecia has its "roots" in the male sex hormone Dihydrotestosterone which triggers progressive miniaturization of the hair follicles based on age and hereditary risk factors. Social factors such as nutrition, diet, lifestyle, stress, medications all are belived to have an impact on the progression of male and female hair loss. However, researchers have recently shown that the more a man smokes, the worse his baldness is likely to be--so add that to your list of reasons to quit! Bauman smoking hair loss baldness

A study of more than 700 Taiwanese men who were aged forty and above suggests that while the risk of hair loss increased with advancing age, those that smoked more than 20 cigarettes per day were more than twice as likely to have moderate or severe hair loss than those who did not smoke.

Researchers suggest that smoking may impact the delicate blood supply to hair follicles and/or damage their genetic material, accelerating the natural progession of hereditary hair loss and prematurely weakening hair quality and coverage of the scalp. This means that the visible signs of hair loss like a receding hairline and thinning in the crown may appear earlier or be more difficult to treat with traditional preventative therapies like Formula 82M Compounded Minoxidil, Low Level Laser Therapy and Finasteride. 

Detrimental effects of smoking may increase the overall amount of transplantation a patient may need using minimally-invasive NeoGraft FUE procedures to restore coverage to the balding areas and also slow down the healing process after their hair transplant procedures.

At Bauman Medical Group, hair loss and hair transplant patients are encouraged to quit smoking as part of a holistic approach to help protect their hair and to recover more quickly from their NeoGraft FUE hair transplant procedures. 

For more information on advanced ways to prevent or reverse hair loss, ask Dr. Alan Bauman a question at http://www.baumanmedical.com

 

 

 

 

 

 


Can a cosmetic product thicken your hair?

What can an over-the-counter cosmetic 'hair thickening' product actually do for someone with hair loss? Well, as a hair transplant surgeon, I always thought "not much!"  However, I've learned over the years that the right haircare and hairstyling products can be VERY helpful for women with thinning hair and also for some men with thinning hair if they have a medium to longer length hairstyle. At Bauman Medical Group, we developed our own "Bauman-MD" line of haircare products including a sulfate-free, color-safe Shampoo and a lightweight UV protectant Conditioner.  As stand-alone products, or for use in conjunction with FDA-approved hair regrowth medications or devices that act directly on the follicles to produce better hair growth, small improvements in hair fiber 'performance' can certainly have an impact on hair styling, managability and scalp coverage.

In 2011, we began working with Dr. Jeni Thomas and her team from Procter & Gamble's Pantene Institute, testing their AgeDefy Hair Thickening product in a blinded clinical trial on nearly 100 women with thinning hair.  The science supported the action of the product, which was to thicken each individual hair fiber, but what would the results be on our the clinical trial participants after 6 weeks and after 12 weeks?

The results so far have been extremely encouraging, so stay tuned for the final report!  See the video below for more information on Pantene Expert Collection AgeDefy Hair Thickening product.

 

 

 

 


Watch Tonight @WPBF25News New Device Helps Measure Hair Quality and Quantity

Tune in to watch Dr. Alan Bauman of Bauman Medical Group and Certified HairCoach Lauren Donald, owner of Bond Street Salon in Delray Beach, discuss this latest breakthrough device and the collaboration between hair stylists and doctors to help those with hair loss.

AutoloGel PRP enhances healing after hair transplantation

AutoloGel™ PRP Enhances Healing After Hair Transplantation

Today, more and more doctors performing hair transplantation are using AutoloGel PRP to help wounds heal faster and reduce the cosmetic downtime from a hair transplant procedure. AutoloGel is used to accelerate the body’s recovery mechanisms and create an optimal environment for wound healing to occur comfortably and quickly.

Studies show that a wound needs three elements to heal naturally and quickly:

  • Moisture
  • Nutrients
  • Cellular growth factors and proteins

Once you hair transplant procedure has been completed, Dr. Alan Bauman and his surgical team will apply AutoloGel PRP immediately after transplantation to stimulate the natural healing process. AutoloGel PRP contains an ingredient obtained directly from your blood, called “platelets.”

PRP – platelet rich plasma – helps keep the wound moist like a biologic bandage and delivers the body’s own growth factors and nutrients.  AutoloGel PRP contains activated platelets and promotes natural healing without side effects or risks.

Platelets are crucial to the healing of wounds.  In order for a wound to heal naturally, it must have the growth factors provided by platelets.  PRP harnesses each person’s own natural healing processes, delivering the growth factors and nutrients that help cells grow and new tissue to form.  PRP can restore the balance in the wound environment to help hair transplants heal naturally with less redness, less crusting and less swelling.

Dr. Alan J. Bauman and every member of his hair transplant team have successfully completed the Cytomedix™ AutoloGel System Certification Training on the AutoloGel System for Surgical Hair Restoration as of August 24, 2011.  Dr. Bauman was one of the first hair transplant surgeons in the world to have his entire surgical team certified to offer AutoloGel PRP wound healing.

AutoloGel PRP reduces scalp scabbing, swelling and redness

A study by RJ Reese, shows that patients receiving AutoloGel PRP after hair transplant had improved healing compared to those who did not receive AutoloGel.

All PRP’s are not alike.  Only one is FDA-cleared for wound care: AutoloGel PRP. Because the term PRP can be applied to any platelet rich plasma product, it may be misleading.  PRP products can vary according to their production process and the end results can be vastly different.   There is only one PRP available that is cleared by the U.S. Food and Drug Administration (FDA) for wound care: AutoloGel PRP.  Dr. Alan J. Bauman and the surgical team at Bauman Medical Group is proud to offer the only FDA-approved PRP regimen with every single hair transplant procedure performed. 

References

Reese RJ, A single-blinded, randomized controlled study of the use of autologous platelet rich plasma (PRP) as a medium to reduce scalp hair transplant adverse events. Hair Transplant Forum Int’l, March/April 2008:pp 51-52.

 

www.autologel.com

www.cytomedix.com

www.prphairrestoration.com

www.baumanmedical.com