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Use of Platelet Rich Plasma Gel on Wound Healing: A Systematic Review and Meta-AnalysisePlasty: Vol. 11

There were 21 publications that were RCT or comparative non-RCT designs in this systematic review. Given the physiological and healing differences between acute and chronic wounds, the citations were divided by study design and by type of wound prior to review and meta-analysis. The primary outcome assessed in this systematic review was complete healing. In both chronic and acute wound studies, complete wound closure was more likely in wounds treated with PRP therapy. Similar partial healing and wound area/volume reduction outcomes were noted more frequently with the PRP-treated wounds likely because the therapy is discontinued once the wound begins healing. This meta-analysis and other systematic reviews show PRP has sufficient efficacy to stimulate healing in stalled wounds. One systematic review concluded that the percentage of total healing in PRP-treated skin ulcers consistently increased compared to controls.7 The meta-analysis of chronic wound studies confirmed the use of PRP treatment favored complete healing compared to control care. Other systematic reviews on PRP therapy reached the same conclusions.7-9 One systematic review went so far as to conclude that based on the meta-analysis and scientific evidence regarding consistent favorable outcomes, PRP is a treatment of choice for the topical care of wounds.9


This is an impressive collection of PRP literature and certainly supports the use of PRP as a wound healing treatment and confirms what we are seeing when we use PRP for wound healing in hair transplants. --Dr. Alan J. Bauman.

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