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March 2022

Exosome Market Report 2022 from BioInformant

The Global Exosome Market - Market Size, Forecast, Trials and Trends 2022

by Cade Hildreth (BioInformant) @StemCellMarket

original article: https://bioinformant.com/product/exosome-market-report/

Exosome Market Size | Exosome Market Report

Market Report, 312 Pages, May 2022

Exosomes are extracellular vesicles (EVs) of endosomal origin that range in size between 30 and 150 nanometers. Exosomes are secreted by a wide range of cells, since virtually all living cells utilize exosome-mediated communication. Exosomes carry cell-specific cargos of proteins, lipids, and nucleic acids that are selectively taken up by recipient cells.

Exosome technologies have been developing rapidly in recent years and substantial growth is expected for the market as they get integrated into the fields of liquid biopsy, precision medicine and regenerative medicine. In particular, cancer derived exosomes influence the invasive potential of cells by regulating angiogenesis, metastasis, and immunity, making them an extremely useful source of biomarkers for use in cancer detection, diagnosis, and therapeutic selection.

The cargo contained within exosomes can offer prognostic information for range of diseases—including cardiovascular, renal, neurodegenerative, and metabolic diseases—as well as cancer.  Researchers investigating exosome biomarkers have discovered, identified, and reported the presence of hundreds of biomolecules within the lumen of exosomes. This discovery has compelled a rapid rise in exosome-related cancer biomarker research, including the use of exosomes for the detection, monitoring, and treatment of a diverse range of oncologic conditions.

Importantly, exosomes are present within a diverse range of biofluids, including serum, plasma, urine, seminal fluid, CSF, saliva, tears and breast milk. For this reason, exosome-based diagnostics are minimally invasive, offering ease of use and speed of detection. Exosomes can also act as prognostic indicators and predictors of a patient’s response to a specific course of treatment.

Exosomes are also being explored for their use as cell-free therapeutics. For example, if a patient has a disease caused by a missing or defective protein or microRNA, the patient’s exosomes can be isolated, modified with the appropriate siRNA or protein, and injected back into the patient for treatment. Numerous approaches are being researched for creating drug-loaded exosomes and exosomes themselves can exert powerful effects. For example, mesenchymal stem cell (MSC) derived exosomes have the capacity to suppress inflammation, prevent scar tissue formation, and mediate a healthy immune response.

The Era of Exosomes

For these reasons, exosomes have gone from being overlooked to rapidly gaining momentum as a novel strategy for accessing the therapeutic effects of cells without the risks and difficulties of administering cells to patients. Although exosomes were discovered more than 30 years ago, it was not until recently that the scientific community began to give credit to exosomes for a range of promising traits.

When exosome publications are analyzed, U.S. authors have published approximately 40% of the articles and China comes in second place. When the term “exosome” is searched in the scientific literature, Dr. Susanne Gabrielsson from the Karolinska Institutet in Sweden is the leading author. When the term “extracellular vesicles” is searched, Unicyte AG, a regenerative medicine unit of Fresenius Medical Care, takes the lead. Headquartered in Switzerland, the company has published more than 100 papers on exosomes and extracellular vesicles in combination with Professor Giovanni Camussi.

To date, three pharma companies (Takeda, Jazz Pharmaceuticals, and Roche Pharmaceutical Company) have signed partnership deals with exosome companies offering payment terms structured to deliver at or around $1 billion dollars. Within the past 5 years, there has been at least 7 partnership deals within the exosome industry, 8 large venture capital events, and 2 landmark acquisitions.

Globally, there are at least 204 clinical trials focusing on exosome-related studies. Of these, 114 trials are evaluating exosome-based therapeutics and 74 trials are testing exosome-based diagnostic tests. Currently, 93 of the exosome trials (45%) are observational studies and 111 of them (55%) are interventional studies. The exosome industry has also achieved two approvals of FDA-approved diagnostic tests: Bio-Techne’s ExoDx Prostate IntelliScore Test for prostate cancer and Guardant’s 360 CDx test for non-small cell lung cancer.

Exosome Market Forces

To characterize the rapidly expanding exosome market, BioInformant has released a 312-page global market report that explores growing demand for exosome therapeutics, diagnostics, research tools, and manufacturing technologies. The report reveals trend rate data for exosome patents, grants, scientific publications, and clinical trials.

It highlights information about exosome industry partnerships, merger and acquisition (M&A) activity, and financing events. It features company profiles for 118 global competitors from across the exosome marketplace. Importantly, it presents market size determinations by market segment with forecasts through 2028.

Today the exosome industry is witnessing:

  • A surging number of scientific papers investigating exosomes and their applications
  • Rising numbers of clinicals trials investigating exosome therapeutics and diagnostics
  • Swelling appetite among investors for exosome technology
  • An increasingly competitive IP environment
  • A diverse range of co-development partnerships
  • Proliferating numbers of exosome competitors in all major life science markets worldwide

This global strategic report about the exosome industry reveals:

  1. The clinical pipeline for exosome therapeutics
  2. Clinical trial activity by type, region, phase, and sponsor
  3. Exosome industry events, including M&A activity, financing events, and IPOs
  4. Strategic partnerships and co-development agreements
  5. Competitors composing the global marketplace, including core technologies and products under development
  6. Market size determinations by market segment, with forecasts through 2030
  7. Exosome industry trends, competitive opportunities, and future directions
  8. And so much more

With the competitive nature of this global market, you don’t have the time to do the research. Claim this report to become immediately informed, without sacrificing hours of unnecessary research or missing critical opportunities.

About BioInformant

With an online readership of nearly one million viewers per year, BioInformant is a U.S. market research firm with nearly 15 years of experience. As the first and only market research firm to specialize in the stem cell industry, BioInformant research has been cited by the Wall Street Journal, Xconomy, and Vogue Magazine. Headquartered in Washington, DC, BioInformant is strategically positioned to be near the National Institutes of Health (NIH), the U.S. FDA, the Maryland Biotech Corridor, and policy makers on Capitol Hill. 

The content within this report was compiled using a diverse range of sources, as described in this Research Methodology.

View Table of Contents: The Global Exosome Market – Market Size, Forecast, Trials and Trends, 2022


What To Do When Natural Hair Growth Treatments Are Not Enough

What should you do when your natural hair growth treatments are not "enough...?"

So, you’ve been disciplined with your vitamins, herbs, supplements, nutritionals, and nutraceuticals for hair regrowth. You’ve been diligently applying the recommended natural herbal topical lotions as recommended. You’ve been using the appropriate hair growth shampoos and conditioners… and you have likely experienced a slowing of hair loss progression and probably noticed even a bit of regrowth in some areas, which is fantastic for non-drug treatments. You’ve done everything “right” so far. 

However, perhaps you want to see more?  More regrowth. More thicker hair. More volume and more coverage, too? No worries!

It’s totally OK to want more from your natural hair regrowth regimen!  It’s completely natural to see your “new normal,” even if it’s improved from where you were, to now be “not enough.”

What can you do to further fight hair loss and improve hair growth?

You may have already been to your stylist or traditional salon. You may even have visited a popular non-medical hair growth salon, like Harklinikken, or if you’re lucky, a Certified Trichologist (a non-medical person who specializes in scalp health and hair growth). 

You may have even been to your local dermatologist for some hair loss advice at some point. But, the chances are, you have NOT gotten an opinion from a full-time board-certified Hair Restoration Physician--a doctor who is an experienced and credentialed professional in the highly specialized field of medical hair restoration. [Did you know there are only about 200 ABHRS board-certified Hair Restoration Physicians in the world, and even fewer have been accepted by the International Alliance for Hair Restoration Surgeons (IAHRS)?]

What Can an ABHRS Board-Certified Hair Restoration Physician like Dr. Alan Bauman Do For You?

Diagnose: Without the correct hair loss diagnosis, your hair regrowth treatments are not likely to work. (This is why DIY treatments often don’t work--most people don’t know what hair loss condition or conditions they are treating.) Getting to an accurate diagnosis requires a detailed history of your hair loss, medical conditions and risk factors, microscopic assessments of your scalp, and may require blood tests or biopsies. 

Measure: If you don’t measure your baseline, tracking and judging improvements over time takes at least 400% longer to judge! (Remember, you can’t manage what you don’t measure.) At Bauman Medical, we measure every patient, every visit, every time!

Follow-up: During your follow-up appointments, we make sure your regimen is up to date, and you are performing the treatment regimen properly.  Nearly 1 in 3 patients have been making a ‘mistake’ in their regimen that is caught and remedied during their first follow-up appointment! Are new treatments available? We will let you know!

Adjust: If your regimen needs a boost because your stress level, health status, or hair loss status has changed, additional and more powerful therapies and treatments can be added. For example, you’ve been using a popular over-the-counter topical minoxidil treatment, but you’ve learned that the compounded prescription versions, like Formula 82M, are stronger and have fewer side effects. Or, maybe you’ve been using a consumer laser therapy device that looks like a big plastic bike helmet and want something more portable, more powerful and medical-grade, like the Turbo LaserCap.  

If you'd like to investigate what else you could be doing to help your hair regrowth, prevent further loss, and assess (or re-assess) your hair status, just request a new hair loss consultation or follow-up consultation with ABHRS Certified Hair Restoration Physician, Dr. Alan J Bauman MD, here at https://www.baumanmedical.com/schedule-consultation and our team will be happy to assist you.