Photo: Hair is seen growing out of skin cells derived from iPS cells and grafted onto the belly of a mouse. | Riken / kyodo
Japanese scientists said Saturday they have bioengineered the skin organ known as the integumentary system in mice using induced pluripotent stem (iPS) cells.
The achievement is likely to lead to further progress in regenerative medicine to treat severe burns, skin diseases and hair loss as the organ contains all the layers of skin tissues and appendages, such as hair follicles and sebaceous glands.
The group, made up of members from the Riken research institute, Tokyo University of Science, Kitasato University, Organ Technologies Inc. and others, cultured iPS cells from mice in vitro for one week and observed the formation of embryoid bodies with epithelial and mesenchymal cells. Next, the team, led by Riken’s Takashi Tsuji, transplanted some 30 such bodies with collagen gel in live mice.
Somewhat similar to the work that's been done at Sanford Burnham in California, Japanese scientists have grown hair follicles from bioengineered skin cells using iPS (induced pluripotent stem cells) in mice. Although there is a long way to go to achieve "unlimited" hair for humans, these research breakthroughs the beginning of stem cell hair loss "cures" which may be helpful for those suffering from various forms of alopecia. Male and female hair loss sufferers often lose self-esteem and self-confidence as coverage of the scalp diminishes due to hereditary (androgenetic alopecia) and other baldness conditions.
At Bauman Medical, we watch these stem cell hair growth breakthroughs with great anticipation and excitement and are looking forward to the day that this kind of therapy will be available for our hair loss patients! Sincerely, Alan J. Bauman, M.D. - Diplomate, American Board of Hair Restoration Surgery
This is a reprint of a MedicalResearch.com Interview with: Dr. Nana Keum, PhD Department of Nutrition Harvard T.H. Chan School of Public Health Boston, MA
Medical Research: What is the background for this study? What are the main findings?
Dr. Keum: Male pattern baldness, the most common type of hair loss in men, is positively associated with androgens as well as IGF-1 and insulin, all of which are implicated in pathogenesis of colorectal neoplasia. Therefore, it is biologically plausible that male pattern baldness, as a marker of underlying aberration in the regulation of the aforementioned hormones, may be associated with colorectal neoplasia. In our study that examined the relationship between five male hair pattern at age 45 years (no-baldness, frontal-only-baldness, frontal-plus-mild-vertex-baldness, frontal-plus-moderate-vertex-baldness, and frontal-plus-severe-vertex-baldness) and the risk of colorectal adenoma and cancer, we found that frontal-only-baldness and frontal-plus-mild-vertex-baldness were associated with approximately 30% increased risk of colon cancer relative to no-baldness. Frontal-only-baldness was also positively associated with colorectal adenoma.
Medical Research: What should clinicians and patients take away from your report?
Dr. Keum: While the relationship between male pattern baldness and prostate cancer risk has been widely examined, to our knowledge, this study represents the first to report a potential relationship between male pattern baldness and the risk of colorectal neoplasia. Thus, our findings should be confirmed in other studies before making definite clinical recommendations. Yet, in the meantime, it may be prudent for males with frontal-only-baldness or frontal-plus-mild-vertex-baldness at age 45 years, although their elevated risk is modest, to consult physicians about colonoscopy screening guidelines.
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Keum: To better understand etiologic mechanism linking male pattern baldness to colorectal neoplasia, future studies are warranted to examine the association of sex hormones, IGFs, and insulin in relation to subtypes of male pattern baldness.
Hair is often an important outward sign of internal health and hair loss conditions are often associated, exacerbated or triggered by medical conditions. In this recent study we see the first published correlation between subtypes of hereditary male pattern baldness and the appearance of and increased risk of neoplastic colon polyps or colon cancer. --Dr. Alan Bauman
The benefits of having a topical anti-androgen to treat the progression of Male Pattern Hair Loss or Androgenetic Alopecia is an exciting development to contemplate. It is interesting to see that Cassiopea/Cosmo Pharmaceuticals is undertaking a Phase II proof-of-concept clinical trial in the U.S. using their famed CB-01-03 anti-androgen in a new formulation called Breezula. Here is some information from their website. --Dr. Bauman
Breezula™ is the brand name of our anti-androgen-containing composition for the treatment of AGA. Breezula™ is topically delivered to the scalp to reduce the hair miniaturization process that, if not controlled, shrinks the follicle, causing hair thinning and, ultimately, hair loss. Breezula™ is currently undergoing a Phase II proof-of-concept clinical trial in the United States.
Breezula™ is a different formulation of the same API contained in Winlevi™. Breezula™ contains a 5% concentration of this API in a lotion designed to penetrate the scalp.
MECHANISM OF ACTION
Breezula™ acts at cutaneous level on the scalp. It antagonizes the negative effects of dihydrotestosterone, the androgen that is the major contributing factor in AGA, on the dermal papillae, small structure in the skin that nourish the hair follicles. Breezula™ also reduces the skin’s production of prostaglandin D2, a hormone-like compound that, in elevated levels, can inhibit hair growth. Finally, Breezula™ helps to control sebum secretion, ultimately reducing hair miniaturization and dermal inflammation.
Breezula™ does not interfere with the hormonal and, in particular, androgenic profile of patients; libido and sexual behavior are unaffected in clinical trials to date.
For information on the latest available treatments for hair loss in men and women, visit http://www.baumanmedical.com and schedule a consultation.
Is shedding normal after PRP Platelet Rich Plasma Hair Regrowth treatment using BioD Extracellular Matrix ECM?
In a word, YES. Because of the natural cycling of hair follicles (on and off, essentially) when you stimulate the hair follicle using a strong hair regrowth treatment like PRP, LaserCap or Capillus laser therapy, compounded minoxidil Formula 82M, etc. it is verycommon to see a short term shedding phase.
When does shedding after PRP+BioD ECM typically start? Post-PRP shedding typically starts 6 weeks after treatment.
How long does shedding last after PRP+BioD ECM treatment? Post-PRP shedding could last 8-10 weeks.
Shedding can often be concerning for those experiencing hair loss and it is common for patients to call or email their hair doctor or HairCoach during this time describing shedding amounts that are more than double their normal rate per day.
The good news is that when you compare treatment zone HMI (Hair Mass Index) measured with the HairCheck Trichometer at 90 days after the treatment and compare those with the baseline measurements done prior to the treatment, you will nearly ALWAYS see some significant improvement... provided you had PRP with BioD or ACell Extracellular Matrix.
Hair growth improvements as measured with HMI in the treatment area will typically continue to improve for about 9-12 months with PRP+BioD and the plateau may last up to two years. [Bauman AJ - Novel Use of Cryopreserved Amniotic Tissue with PRP for Hair Regrowth - ISHRS Scientific Meeting Chicago Sep 2011] Visually, the area will begin to improve in about 6 months and full results from the treatment will be seen at around 12 months.
Here is my old blog post regarding strong hair regrowth treatments and temporary shedding due to stimulated hair follicle cycling:
Shedding on Minoxidil, Propecia/Finasteride or Laser Therapy
Are you seeing excessive shedding after just beginning hair loss treatment with minoxidil (formula 82m or rogaine), laser therapy (lasercap or other)? You might be having the "Dread Shed!" But don't worry, keep up with the treatment... here's why:
Keep in mind that any regimen (medication or laser therapy) that stimulates follicles to switch into a growth phase can cause shedding. Because all hair follicles cycle-on and cycle-off over the course of your life, shedding is a VERY poor barometer for the measurement of hair loss or hair growth. Regardless of treatment, the more hair follicles you have, the more shedding you will have. "Resting" follicles may still contain a hair-shaft. When you apply minoxidil, for example, and the follicle "switches on" and the newly growing hair pushes out the old, resting hairshaft. The result: a shed. It is my feeling that any hair that is shed from starting a particular therapy wasn't in an anagen/growth phase anyway.
Remember that minoxidil/rogaine is a proven 'anagen-stimulator' which shifts restingfollicles into growing follicles. Female pattern hair loss (androgenetic alopecia) is characterized by miniaturizing follicles and a shortening of the natural growth-phases of the follicles.
Shedding when starting minoxidil, laser, or propecia (if it is noticeable) typically occurs within the first two to eight weeks of therapy. Keep in mind that it normally takes 10-20 weeks for microscopic hair density to peak with minoxidil AND six to twelve months to see visible results of the growth with minoxidil.
Nice to see some of the new hair loss treatments for women gain some attention from the New York Times. They covered therapies like stem cells, PRP, minoxidil, laser therapy and hair transplantation.
When it comes to PRP and other hair regrowth treatments, not all physicians are performing the same "recipe" or preparation. Instead of multiple, monthly injections the addition of extracellular matrix products, like ACell or BioD, seems to help results from Platelet Rich Plasma last longer and be stronger.
New pharmacy-compounded minoxidil preparations like Formula 82M reduce side effects of the over-the-counter Rogaine and generic versions. Less greasy and irritating, Formula 82M minoxidil is a strong hair growth treatment which contains ingredients which improve the penetration and efficacy of the minoxidil.
The number of laser therapy devices available for patients have certainly increased dramatically over the years since we started with in-office laser therapy at Bauman Medical Group in 1999. FDA-cleared laser hoods, clinical units, combs, hats, helmets and caps vary in cost, power and convenience. Savvy consumers will seek out powerful laser devices that are hands-free which sit underneath standard ball caps, hats, scarves or other headwear.
Minimally-invasive hair transplant procedures, like NeoGraft FUE, are appropriate for women who want to lower their hairline, add density to their temple areas or frontal zones without the downtime, discomfort and restrictions of old-style linear harvesting requiring a scalpel, stitches or staples.
For more information about the latest advancements in hair loss diagnosis, hair loss treatments and hair transplants for women, visit www.baumanmedical.com
Reportedly, research scientists at Sanford-Burnham Medical Research Institute have used human stem cells to generate new hair growth. While this is not yet a cure that is "ready for prime time," it may be the first step in a successful stem cell based treatment that could provide unlimited hair for transplantation. This kind of cell therapy has yet to be tested or proven but staff (and patients) of Bauman Medical Group are excited to see if this develops into a viable baldness treatment. Congratulations to Dr. Terskikih and his team on this incredible breakthrough. [photo courtesy: Sanford-Burnham]
In a new study, Sanford-Burnham researchers have used human pluripotent stem cells to generate new hair. The study represents the first step toward the development of a cell-based treatment for people with hair loss. In the United States alone, more than 40 million men and 21 million women are affected by hair loss. The research was published online in PLOS ONE. “We have developed a method using human pluripotent stem cells to create new cells capable of initiating human hair growth. The method is a marked improvement over current methods that rely on transplanting existing hair follicles from one part of the head to another,” said Alexey Terskikh, Ph.D., associate professor in the Development, Aging, and Regeneration Program. “Our stem cell method provides an unlimited source of cells from the patient for transplantation and isn’t limited by the availability of existing hair follicles.” The research team developed a protocol that coaxed human pluripotent stem cells to become dermal papilla cells. They are a unique population of cells that regulate hair-follicle formation and growth cycle. Human dermal papilla cells on their own are not suitable for hair transplants because they cannot be obtained in necessary amounts and rapidly lose their ability to induce hair-follicle formation in culture. “In adults, dermal papilla cells cannot be readily amplified outside of the body and they quickly lose their hair-inducing properties,” said Terskikh. “We developed a protocol to drive human pluripotent stem cells to differentiate into dermal papilla cells and confirmed their ability to induce hair growth when transplanted into mice.” - See more at: http://beaker.sanfordburnham.org/2015/01/using-stem-cells-to-grow-new-hair/#sthash.8kEpHh8e.dpuf
At Bauman Medical Group's Hair Transplant and Hair Loss Treatment Center, we will be watching this breakthrough carefully! Sincerely, Dr. Alan Bauman
BOSTON (CBS) – Scientists at Yale may have discovered quite the off-label use for an FDA-approved arthritis drug.
During a trial which stretched for eight months, a 25-year-old man with almost no hair on his body grew a full head following treatment with the drug. He reported no noticeable side effects.
The patient was suffering from a rare, highly visible disease known as alopecia universalis, which has no cure or approved long term treatment.
The disease causes the loss of almost all body hair.
According to scientists involved in the trial, the patient also grew eyebrows, eyelashes, and facial, armpit, and other hair.
“The results are exactly what we hoped for,” said Brett A. King, M.D., assistant professor of dermatology at Yale University School of Medicine and senior author of a paper reporting the results online June 18 in the Journal of Investigative Dermatology. “This is a huge step forward in the treatment of patients with this condition. While it’s one case, we anticipated the successful treatment of this man based on our current understanding of the disease and the drug. We believe the same results will be duplicated in other patients, and we plan to try.”
The drug, called tofacitinib citrate has also been used successfully for treating psoriasis...
It will be interesting to see if this result can be duplicated in other patients suffering from Alopecia Univeralis! -Dr Bauman
By age 50, nearly half of all men and women will experience some degree of hair thinning. Hair loss affects roughly 35 million men and 21 million women in the United States. This course will give participants the power to improve the well-being of their patients! Learn to consult and evaluate; measure and diagnose; identify risk factors; recommend and prescribe results-oriented protocols; and treat, track & follow-up.
Joseph Purita, MD, is Director of the Institute of Regenerative and Molecular Orthopedics in Boca Raton, Florida and board certified in Orthopedic Surgery. Dr. Purita is a Fellow of the American College of Surgeons, Fellow of the American Academy Orthopedic Surgeons, and is certified in Age Management Medicine. Dr. Purita’s breakthrough stem cell treatments have made him a household name amongst professional athletes and a frequently invited faculty member and visiting professor at major international medical conferences and institutions. A pioneer in stem cell orthopedics, Dr. Purita has performed thousands of in-office mesenchymal and bone marrow stem cell treatments, platelet-rich plasma and growth factor injections as effective non-surgical solutions for common musculoskeletal conditions.
Michael Hamblin, PhD, is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School and a member of the Affiliated Faculty of Harvard-MIT Division of Health Science and Technology. He has published over 185 peer-reviewed articles and over 150 conference proceedings, book chapters and international abstracts on phototherapy. Dr. Hamblin has chaired an annual conference at SPIE entitled “Mechanisms of Low Level Light Therapy” for the past eight years. Dr. Hamblin’s interest in elucidating the basic molecular and cellular mechanisms of LLLT has led to the many of the prevailing theories on low-level laser’s effect on hair follicles and hair regrowth dosing protocols.
Alan Bauman, MD, is the Founder and Medical Director of Bauman Medical Group in Boca Raton, FL dedicated exclusively to the treatment of hair loss in men and women. Dr. Bauman is one of only approximately one-hundred doctors certified by the American Board of Hair Restoration Surgery and one of only fifty doctors recommended by the American Hair Loss Association in the world. Dr. Bauman has treated over 15,000 hair loss patients and performed over 6,000 hair transplant procedures.
Select topics to include:
• Pros and Cons of Traditional and Compounded Topical and Oral Medical Therapies
• Use of Cell Therapy, including Platelet Rich Plasma, Growth Factors & Stem Cells
• Etiology & Psychosocial Impact of Hair Loss
• Role of Hormones & Hair Loss
• Beneficial and Detrimental Nutritional Supplements
• Mechanism and Benefits of Laser and Light-based Protocols on Hair Follicle Physiology
• Consulation, Diagnosis, Evaluation and Hair Growth Tracking Equipment and Methods
It's been 50 years since the U.S. Surgeon General warned about the health risks of smoking, cutting smoking rates in half. As some smokers still light up, do they realize the impact on hair, hair loss and baldness?
Male pattern baldness or Androgenetic Alopecia has its "roots" in the male sex hormone Dihydrotestosterone which triggers progressive miniaturization of the hair follicles based on age and hereditary risk factors. Social factors such as nutrition, diet, lifestyle, stress, medications all are belived to have an impact on the progression of male and female hair loss. However, researchers have recently shown that the more a man smokes, the worse his baldness is likely to be--so add that to your list of reasons to quit!
A study of more than 700 Taiwanese men who were aged forty and above suggests that while the risk of hair loss increased with advancing age, those that smoked more than 20 cigarettes per day were more than twice as likely to have moderate or severe hair loss than those who did not smoke.
Researchers suggest that smoking may impact the delicate blood supply to hair follicles and/or damage their genetic material, accelerating the natural progession of hereditary hair loss and prematurely weakening hair quality and coverage of the scalp. This means that the visible signs of hair loss like a receding hairline and thinning in the crown may appear earlier or be more difficult to treat with traditional preventative therapies like Formula 82M Compounded Minoxidil, Low Level Laser Therapy and Finasteride.
Detrimental effects of smoking may increase the overall amount of transplantation a patient may need using minimally-invasive NeoGraft FUE procedures to restore coverage to the balding areas and also slow down the healing process after their hair transplant procedures.
At Bauman Medical Group, hair loss and hair transplant patients are encouraged to quit smoking as part of a holistic approach to help protect their hair and to recover more quickly from their NeoGraft FUE hair transplant procedures.
There are several steps involved with PRP Hair Regrowth Treatment at Bauman Medical Group, which takes approximately one-hour in the office. Once the patient and area of hair loss is evaluated and selected for treatment, the process may begin.
1) Scalp Preparation - An antiseptic scalp-wash is performed. At Bauman Medical, we use a robotic scalpwash device which delivers antiseptic shampoo and a scalp massage.
2) Evaluation & Measurement - The area of hair loss is measured and evaluated using HairCheck (Cross Sectional Hair Bundle Trichometry/Hair Mass Index measurements) as well as HairCam (Microscopic Dermoscopy) and standardized 'global' photography.
3) PRP Production - Phebotomy is peformed (blood draw) and the blood sample is processed into PRP Platelet Rich Plasma using a special centrifuge. At Bauman Medical, we use the FDA-approved Cytomedix "AutoloGel" process. All of our medical technicians have been AutoloGel-Certified since 2011.
4) Anesthesia - Local anesthetic is applied to the scalp using the FDA-Approved "Ouchless Needle" for a completely painless procedure.
5) PRP Application - The PRP is mixed with extracellular matrix (ECM) and injected into the scalp. At Bauman Medical, we use either ACell/Matristem (porcine urinary bladder ECM) or BioD/AmnioMTM (human amniotic ECM + stem cells).
6) Microtrauma - Microtrauma is performed without damaging rollers by using a depth-adjustable automated MicroPen microneedling device. Then, a gentle scalpwash is performed.
7) Low Level Laser Therapy - A 15 minute laser therapy treatment is applied using an in-office 107 diode 650nm 5mw/laser diode device.
8) Instructions/Follow-up - No bandage is needed. Patients may shampoo their scalp that evening and use mild analgesics (tylenol) if necessary. Follow-up measurement and evaluations are scheduled every four weeks.
Results expectations of PRP Hair Regrowth: Based on our experience at Bauman Medical Group and scientific reports, we have noticed that Hair Mass Index measurement start to improve in about 8-12 weeks, and plateau within 9-14 months. Repeat treatments will likely be needed to maintain the improved hair growth every 12-18 months. Areas of the scalp where significant numbers of miniaturized hair follicles exists tend to improve more dramatically than other zones.
Are You A Candidate for PRP Hair Regrowth? To find out if you are a candidate for PRP hair regrowth treatments with ACell or BioD amniotic ECM + stem cells, please contact Dr. Alan Bauman via http://www.baumanmedical.com or call 561-394-0024.