hair growth was stimulated by SFRP1 antagonist WAY-316606 via Wnt signaling

A novel strategy for stimulating hair growth using WAY-316606, an SFRP1 Antagonist via Wnt signaling pathway...

Journal.pbio.2003705.g003
Fig3: Inhibiting SFRP1 activity with WAY-316606 enhances human hair growth, increases K85 protein expression, and inhibits spontaneous catagen ex vivo.
 
Recently touted in this popular news story entitled "Shampoo containing brittle bones drug allegedly triggers hair growth" http://www.foxnews.com/health/2018/05/09/shampoo-containing-brittle-bones-drug-allegedly-triggers-hair-growth.html, the scientific research behind this story and WAY-316606 is true and not "fake news," but the title is VERY misleading. This potentially hair-growing compound is NOT contained in a shampoo or gel in the ex-vivo studies (the studies were done in a petri dish, not on a scalp), and an over-the-counter remedy based on this technology is very, very far off--and may never come to fruition. Here is an excerpt from the original study below... --Dr. Alan Bauman, MD, ABHRS, IAHRS, FISHRS
 

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

Nathan J. Hawkshaw, Jonathan A. Hardman, Iain S. Haslam, Asim Shahmalak, Amos Gilhar, Xinhong Lim, Ralf Paus

Published: May 8, 2018 https://doi.org/10.1371/journal.pbio.2003705

http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.2003705

Abstract

Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth–modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth–promoting molecular targets. Through microarray analysis we identified the Wnt inhibitor, secreted frizzled related protein 1 (SFRP1), as being down-regulated in the dermal papilla (DP) of CsA-treated human scalp hair follicles (HFs) ex vivo. Therefore, we further investigated the function of SFRP1 using a pharmacological approach and found that SFRP1 regulates intrafollicular canonical Wnt/β-catenin activity through inhibition of Wnt ligands in the human hair bulb. Conversely, inhibiting SFRP1 activity through the SFRP1 antagonist, WAY-316606, enhanced hair shaft production, hair shaft keratin expression, and inhibited spontaneous HF regression (catagen) ex vivo. Collectively, these data (a) identify Wnt signalling as a novel, non–immune-inhibitory CsA target; (b) introduce SFRP1 as a physiologically important regulator of canonical β-catenin activity in a human (mini-)organ; and (c) demonstrate WAY-316606 to be a promising new promoter of human hair growth. Since inhibiting SFRP1 only facilitates Wnt signalling through ligands that are already present, this ‘ligand-limited’ therapeutic strategy for promoting human hair growth may circumvent potential oncological risks associated with chronic Wnt over-activation.

Author summary

Hair loss is a common disorder and can lead to psychological distress. Cyclosporine A, a fungal metabolite commonly used as an immunosuppressant, can potently induce hair growth in humans. However, it cannot be effectively used to restore hair growth because of its toxic profile. In this study, we used Cyclosporine A as a lead compound to identify novel therapeutic targets that can aid the development of new hair growth–promoting agents. Through microarray analysis, we found that the level of the secreted Wnt inhibitor, SFRP1, was significantly reduced by Cyclosporine A. This inspired us to design a new pharmacological approach that uses WAY-316606, a reportedly well-tolerated and specific antagonist of SFRP1, to prolong the growth phase of the hair cycle. We show that WAY-316606 enhances human hair growth ex vivo, suggesting that it is a more targeted hair growth promoter with the potential to treat human hair loss disorders.

 

At Bauman Medical, we are closely monitoring these types of research studies which may give rise to safe, therapeutic treatments for hair loss for our patients in the future. Stay tuned for further updates at https://www.baumanmedical.com Hair loss suffers may request a private Virtual Consultation (Skype or FaceTime) or In-Person Consultation with #1 Top Hair Restoration Surgeon, Dr. Alan J. Bauman, MD, ABHRS, IAHRS, FISHRS.

 


Dr. Alan J. Bauman MD is recommended by the American Hair Loss Association

Verified

Alan Bauman, MD

Boca Raton, Florida http://www.baumanmedical.com
Validated Recommended American Hair Loss Association Surgeon
Years: 2002-2018

Alan Bauman, MD located in Boca Raton, Florida is a recommended hair transplant surgeon of The American Hair Loss Association

Make Informed Choices

Alan Bauman, MD is also recommended by the elite hair transplant consumer organization, The International Alliance of Hair Restoration Surgeons http://www.iahrs.org/

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Alan Bauman, MD, Adds SmartGraft® To Treatment Portfolio, Producing Natural-Looking FUE Hair Transplant Results From His Florida Practice

Alan Bauman, MD, Adds SmartGraft® To Treatment Portfolio, Producing Natural-Looking FUE Hair Transplant Results From His Florida Practice

Revolutionary Technology Restores Hairlines For Men And Women

Boca Raton, Florida – May 2, 2018 --  Internationally Renowned Hair Transplant Surgeon Dr. Alan J. Bauman, MD brings SmartGraft®, a minimally invasive and permanent hair restoration treatment for both men and women, to his state of the art practice in Boca Raton, Florida which serves Miami, Palm Beach, Ft. Lauderdale and beyond.

IMG_1089 2-bauman-smartgraft_2016Dr. Bauman is one of only 200 physicians globally to achieve certification from the American and International Board of Hair Restoration Surgery (ABHRS), be an accepted member of the International Alliance of Hair Restoration Surgeons (IAHRS) and also recommended by the American Hair Loss Association. In addition, he has attained the coveted Fellow status within the International Society of Hair Restoration Surgery (FISHRS).

Hair is Dr. Bauman’s passion; he is an Advisory Board Member for the World Trichology Society and is also the author of numerous articles and textbook chapters on the science of hair care and hair transplantation, including eyelash transplant surgery. He is a successful early-adopter and pioneer of some of the most advanced technologies in the effective treatment of hair loss including no-linear-scar FUE or Follicular Unit Extraction, which is why SmartGraft appealed to Dr. Bauman.

As an FUE hair transplant pioneer who has used numerous manual, mechanical and robotic devices over more than 15 years and after extensive internal device testing and research, I can say with great confidence that SmartGraft is a dramatic improvement over previous manual mechanical FUE tools currently on the market,” states Dr. Bauman. “Innovations like the unique closed, climate-controlled internal graft storage and hydration system, programmable microprocessor control, and on-board LED lighting system on the handpiece are improving accuracy, efficiency and, most importantly, our patients’ results.” He details that minimally invasive FUE harvesting of individual follicular units for transplantation with SmartGraft allows patients a faster, more comfortable, less restricted recovery phase compared to old-style linear “strip” harvesting.

[See Dr. Bauman's SmartGraft Results]

Since no wide-shave of the donor area is required, handheld FUE devices such as SmartGraft empower Dr. Bauman and his team to execute traditional transplants for male pattern hair loss, as well as specialty transplants like female hairline lowering, female pattern hair loss, female temple restoration, eyebrow transplantation, beard and body hair harvesting, as well as smaller “no shave” FUE procedures from the scalp for male and female hair loss patients. “With SmartGraft, all patients maintain the benefits of leaving behind absolutely NO telltale linear scar,” adds Dr. Bauman.

01-before-12mos-after-SmartGraft-FUE-hair-transplant-bauman

SmartGraft makes hair replacement a more accessible, effective and realistic option than ever before for both men and women with hair loss, delivering natural-looking outcomes with little downtime. When expertly performed, the treatment is quick, comfortable and permanent.

 

 

 

About Alan J. Bauman, MD, IAHRS, FISHRS, ABHRS:

Alan J. Bauman, M.D. is a full-time board-certified hair restoration physician who has treated over 17,000 patients and performed over 8,000 hair transplant procedures since starting his medical hair loss practice, Bauman Medical, in 1997. Currently located in Boca Raton, Florida, Dr. Bauman received his M.D. degree from New York Medical College and surgical residency training at Mt. Sinai Medical Center and Beth Israel Medical Center in New York. Dr. Bauman is one of approximately only 200 physicians worldwide to achieve the certification from the esteemed American and International Board of Hair Restoration Surgery (ABHRS), is an accepted member of the International Alliance of Hair Restoration Surgeons (IAHRS), and is also recommended by the American Hair Loss Association. Dr. Bauman has achieved the coveted Fellow status within the International Society of Hair Restoration Surgery (ISHRS) and is a frequently invited faculty member at numerous international scientific meetings and live surgery workshops. Dr. Bauman was an early pioneer of no-linear-scar FUE Follicular Unit Extraction hair transplant procedures, designing the first commercially available instrument specifically for FUE called the Bauman MINDEX. He has performed FUE procedures for over 15 years, transplanting nearly three million FUE grafts for his patients over that time. 

This past year, Dr. Bauman was named both a “Top 5 Transformational CEO” and one of “10 CEOs Transforming Healthcare in America” in Forbes, as well as voted North America’s “#1 Top Hair Restoration Surgeon” by Aesthetic Everything. He is a Trustee member and recipient of the Small Business Leader of the Year Award from the Greater Boca Raton Chamber of Commerce. Dr. Bauman has been featured in hundreds of national and international media stories. Personal appearances, interviews and profiles include the Today Show, The Early Show, Good Morning America, Extra, Access Hollywood, The Howard Stern Show, The Doctors, Spencer Kobren’s The Bald Truth, CNN, Dateline NBC and more. Newspaper and magazine articles and feature stories include The New York Times, Newsweek, Cosmo, Elle, Vogue, The CEO Forum, Allure, O – The Oprah Magazine and Men’s Health, among others.

In addition to teaching and lecturing internationally, Dr. Bauman sees patients personally and performs procedures at his state-of-the-art facility in Boca Raton, FL. In-person or Virtual consultations with Dr. Alan Bauman can be requested at https://www.baumanmedical.com/schedule-consultation

 

About FUE or Follicular Unit Extraction

FUE or Follicular Unit Extraction is the least invasive hair transplant graft harvesting technique that leaves absolutely NO telltale linear scar in the donor area and with a more comfortable and less restricted recovery than traditional “Strip Harvest” techniques. Grafts as small as a single hair can be harvested from the Donor Area and when implanted with artistry and precision by an expert surgeon, create an undetectably natural restoration of living and growing hair.

 

About SmartGraft

Vision Medical, Inc. is a leading USA manufacturer that develops and markets medical and aesthetic technology products for the medical and aesthetic markets for worldwide distribution. Vision Medical’s first commercial product, the SmartGraft® Hair Restoration System, uses minimally-invasive vacuum assisted FUE technology for men and women. SmartGraft keeps the newly harvested grafts chilled, hydrated & robust without any exposure to outside air for optimal graft preservation. To learn more about SmartGraft and its technology, visit www.SmartGraft.com.

 

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Patty Mathews: [email protected]

Melissa Ben-Yoseph: [email protected]

 

CONNECT WITH DR BAUMAN

Instagram: @DrAlanBauman @BaumanMedical
Twitter: @DrAlanBauman @Transplant_Hair
Facebook: @BaumanMedicalGroup

https://www.baumanmedical.com


Does Erivedge (visomodegib) Cause Hair Loss?

Screen Shot 2018-03-20 at 8.22.36 AMErivedge & Hair Loss, Hair Thinning

What is Erivedge (visomodegib)?

Erivedge or visomodegib capsule is a prescription oral chemotherapy medication for adults with basal cell carcinoma skin cancer that has spread to other parts of the body or that has come back after surgery or cannot be treated with surgery or radiation. At Bauman Medical, chemo hair loss expert Dr. Alan Bauman has examined, evaluated and successfully treated patients who have experienced hair loss, baldness, hair thinning and-or alopecia from Erivedge (vismodegib).

What is the Mechanism of Erivedge – vismodegib?

Vismodegib is a Hedgehog Pathway Inhibitor. By disrupting the hedgehog pathway signal which drives cancer cell growth, Erivedge prevents the cancer from growing. Hedgehog pathways may also be responsible for many of the side effects of Erivedge. For example, Sonic Hedgehog signaling is required for hair follicle development in a fetus and for regulating hair follicle growth and cycling in the adult.

What are some known side effects of Erivedge visomodegib?

In addition to loss of taste, muscle pain, muscle spasms, nausea, vomiting, birth defects, fetal death, diarrhea and fatigue, Hair Loss, alopecia, and-or thinning of scalp and body hair is a known side effect of Erivedge visomodegib. Your hair may become thin, brittle, or may fall out when taking Erivedge. This means that hair breakage, shedding and changes in texture of your hair are possible side effects. In addition to scalp hair loss, Erivedge can cause loss of any body hair, including pubic, underarm, legs/arms, eyelashes, eyebrows and nose hairs. It is assumed that interruption of the Hedgehog pathway is a possible cause of changes in hair follicle function and hair fiber production in those taking the cancer drug Erivedge visomodegib.

Hair Loss and Erivedge Medication for Cancer

Hair Loss is the second side effect listed in the FDA-approved label for Erivedge and seems to be one of the more common side effects of this chemotherapy drug.

Is vismodegib hair loss permanent?

All of the details of hair loss due to Erivedge vismodegib are not known. Hair usually starts to regrow after the treatment is completed, but could take months or longer to fully regrow. Accounts of incomplete or partial hair regrowth have been reported.

Screen Shot 2018-03-19 at 3.34.45 PMWhat can be done about temporary hair loss or alopecia with Erivedge?

If vismodegib is causing temporary alopecia or hair loss, the use of a 3D-Printed Cranial Prosthesis or non-surgical medical-grade hair replacement system may be an excellent option. A CNC hair prosthesis functions beyond a typical medical wig or hair replacement system.

What should I do if I have hair loss related to Erivedge?

First, notify your prescribing doctor immediately of any side effects with Erivedge.
If hair loss side effects occur, seek out a qualified, credentialed (ABHRS, FISHRS, IAHRS) and experienced Hair Restoration Physician. Seek out an MD who has the ability to scientifically evaluate, measure and monitor your hair loss and hair regrowth and has access to the best treatments available. Bottom line, ask an expert. You may ask Dr. Alan Bauman a question about Erivedge hair loss and receive information about what to do if you experience hair loss with Erivedge vismodegib.

What kind of treatments will help hair regrowth after Erivedge vismodegib?

As long as hair follicles remain viable and not permanently damaged, treatments such as laser therapy (LaserCap 224 or CapillusRX), PRP Platelet Rich Plasma, Topical Formula 82M Minoxidil as well as nutritionals/supplements for hair support (Viviscal Pro, Nutrafol) may be good options. If some hair follicles are irreversibly damaged in small areas, FUE hair transplantation with SmartGraft, NeoGraft or ARTAS robotic-system may be required to restore coverage. If large numbers of hair follicles over a large area of scalp are damaged and do not respond to therapy, non-surgical hair replacement with CNC 3D-printed hair prosthesis may be an option.

Learn more about hair loss from Erividge visomodegib at http://www.baumanmedical.com/visomodegib-erivedge-hair-loss/

 

 


What is SmartGraft FUE hair transplant?

SmartGraft FUE BaumanMedicalWhat is SmartGraft device for FUE hair transplantation?

SmartGraft™ is the fastest, most advanced hand-held device for minimally-invasive FUE Follicular Unit Extraction hair transplant procedures we have ever used at Bauman Medical, allowing for the individual harvesting of follicular unit grafts directly from the Donor Area of the scalp without leaving a linear scar or “zipper” appearance. Shorter FUE procedure times means reduced risks of graft failure and poor growth quality, as well as enhanced patient comfort. SmartGraft, by Vision Medical, also has a complete microprocessor controlled graft extraction and storage system which reduces the risk of damage to the fragile FUE grafts. 

Many, including North America's #1 Top Hair Restoration Surgeon (Aesthetic Everything), Dr. Alan J. Bauman MD, believe that SmartGraft is simply a better or maybe “smarter!” way to perform a hair transplant. SmartGraft is a breakthrough device that helps hair transplant surgeons and their specialized teams perform FUE or Follicular Unit Extraction hair transplantation. Less invasive than traditional linear "strip" harvesting, Follicular Unit Extraction uses no scalpel, no stitches, no staples in the donor area--allowing for faster healing and less discomfort after transplantation.

What is FUE Follicular Unit Extraction?

Hair transplantation is the redistribution of permanent, living and growing hair follicles from the “Donor” Area into a thinning or balding “Recipient” area of the scalp. FUE is a harvesting technique which is less invasive than traditional strip or linear harvesting which requires no scalpel or stitches in the Donor Area. Recovery from FUE procedures is more comfortable and less restrictive than with linear or strip harvesting. The vast majority of patients require absolutely NO strong pain medications during their recovery and can return to non-impact athletic physical activity in just several days.

Dating back prior to 2002, renowned hair loss expert and ABHRS-certified Hair Restoration Surgeon, Dr. Alan J. Bauman, MD, ABHRS was amongst a handful of surgeons worldwide who helped develop instruments for, as well as pioneer, research, teach and train doctors on the minimally-invasive techniques of FUE. Dr. Bauman was the very first board-certified hair transplant surgeon in North America to routinely use Neograft, a motorized hair transplant system for no-linear-scar hair follicle harvesting, starting in 2007. He was also one of the first physicians to use the FDA-approved ARTAS robotic-assisted FUE system. Since 2002, Dr. Bauman and his surgical team have transplanted more than 2,500,000 follicular units using the FUE technique–making Dr. Bauman one of the most experienced FUE surgeons in the world. FUE is the least invasive hair transplant procedure and leaves absolutely NO linear scar. It has less downtime and less discomfort than traditional “linear” or “strip-harvest” procedures.

Will SmartGraft FUE Hair Transplant Look Natural?

The final naturalness and undetectability of a hair transplant relies primarily on the minimally-invasive FUE harvesting method of grafts as small as a single follicle and the artistic ability of the surgeon who creates the sites where the follicles will be implanted. Your surgeon must understand the bounds of naturalness of the hairline design, as well as the relationship of each and every angle, orientation and position of the transplanted hair so that the end result looks natural, and not transplanted. Dr. Bauman is renowned for his artistic approach to hairline design and meticulous execution in his hair transplant procedures. Read patient reviews and ratings as well as see Dr. Bauman's artistic hairline and other transplant results at BaumanMedical.com.

For more information about SmartGraft for FUE procedures or to see if you are a candidate for this type of hair transplant procedure, ask a question at www.BaumanMedical.com/ask-a-question

To schedule a Virtual Consultation with Dr. Bauman from anywhere in the world, visit http://www.baumanmedical.com/schedule-consultation


Hair Transplant Surgeon Dr. Alan Bauman Selected as One of 10 CEOs Transforming Healthcare by Forbes

Screen Shot 2018-01-30 at 6.51.35 AM 

Forbes Features Hair Transplant Specialist Dr. Alan Bauman among 10 CEOs Transforming Healthcare in America

Forbes.com article input from Dr. Bauman included among healthcare leaders from Cleveland Clinic, AARP, Universal Health Services and Boston Children’s Hospital

BOCA RATON, Fla.--(BUSINESS WIRE)--Jan. 30, 2018-- Dr. Alan J. Bauman, MD of Boca Raton, FL (Bauman Medical, www.baumanmedical.com) is a featured participant in a Forbes article titled, “10 CEOs Transforming Healthcare in America.” He joins a select group of key opinion healthcare leaders from across the country providing their personal perspectives, contributions and philosophies with regard to the rapid transition in healthcare and the challenges posed by the growing needs of an aging and more demanding population.

This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20180130006251/en/

Dr. Bauman is the leader in hair restoration—a healthcare segment that impacts upwards of 80 million Americans and has direct correlations to physical and mental well-being. He has led the industry as a pioneer in technologies including robotic-assisted hair transplant surgery and runs the largest, most comprehensive treatment center in America where his Bauman Medical team has treated over 20,000 patients. Dr. Bauman is credited for bringing hair restoration to mainstream America.

“Specifically, Bauman Medical is helping transform healthcare in America through the blending of game-changing technology with experience and artistry. Through the use of robotic technologies and advanced medicine, that includes such procedures as stem cell therapies and PRP, we are operating in the hair restoration and hair transplant sectors on a platform similar to the most advanced medical practices being conducted anywhere in the country,” said Dr. Bauman. “We are transforming healthcare by consistently offering our patients the most innovative, effective and comprehensive options they could find coupled with the most highly trained, customer-focused experience they could want. Everyone who walks in our door is special and we tailor our efforts to their specific needs whether they are with us for a basic scalp assessment or treatment up to and through our 'Hair Like a Boss' concierge experience that caters to a patient’s every need.”

Bauman Medical is leading its sector’s transformation of healthcare by advancing the science and art in the field of hair restoration and hair transplantation. Through the integration of advanced procedures and technologies the team has helped pioneer and champion such minimally invasive techniques as minimally-invasive FUE hair transplantation, PRP Platelet Rich Plasma for hair growth using the EnrichedPRP system from MasterPharm (NY) and Emcyte (FL), 3D-printed Italian medical grade hair replacement prosthesis from Cesare Ragazzi Laboratories (Bologna), the Viviscal Hair Growth Program from Church & Dwight (NYSE:CHD) and many others.

Dr. Bauman and the others featured in the Forbes article were recently recognized for their leadership in The CEO Forum magazine. The CEO Forum is a bi-monthly publication written and delivered in hardcopy to the top 10,000 CEOs in America and digitally to a broader community of 9,800 CEOs. At its core is driving and expressing through its participating CEOs the timeless principles that define personal leadership success and demonstrating business model success. Founded by Robert Reiss who as CEO of the publication and Host of a weekly radio show broadcast on twenty-five AM radio stations with over 600,000 weekly listeners, the property has become a highly useful and informative tool for CEOs and c-suite members, and was cited in 2016 as the #1 podcast for CEOs in America. www.ceoforum.ceo

About Bauman Medical

Bauman Medical was founded in 1997 with a single mission… to improve the physical appearance and in doing so the mental health of its patients through optimum hair health and hair restoration. Dr. Alan J. Bauman, MD, ABHRS, is among a very selected group of physicians worldwide to earn Board Certification from the prestigious American Board of Hair Restoration Surgery (ABHRS) and accepted by the International Alliance of Hair Restoration Surgeons (IAHRS). He has achieved Fellow status with the esteemed International Society of Hair Restoration Surgery (FISHRS). Under the doctor’s leadership, Bauman Medical delivers exceptional and consistent results. In total, Bauman Medical has treated over 20,000 hair loss patients while conducting more than 8,000 surgical procedures since its inception. Through his 501(c)(3) non-profit Bauman Philanthropic Foundation, Dr. Bauman and his team provide pro-bono hair restoration, surgical hair transplant and medical treatment to patients in need. Dr. Bauman was recently voted North America’s #1 Top Hair Restoration Surgeon by Aesthetic Everything. Dr. Bauman is a frequent guest expert and faculty member at many major international medical conferences. In addition to teaching and consulting worldwide, he personally sees patients and performs procedures at Bauman Medical Hair Transplant and Hair Loss Treatment Center — an 11,000 sq. ft. stand-alone medical facility located in downtown Boca Raton, one of the largest facilities of its kind in the country.

To view the Bauman Medical Executive Hair Restoration Experience, please visit, http://www.hairlikeaboss.com

To take a 3-D Video Tour of the Bauman Medical facility and its surroundings, please visit, https://vimeo.com/252345887.

For all media inquiries about Bauman Medical and to speak with Dr. Bauman, please contact Shep Doniger at BDCG at 561-637-5750 or [email protected].

 

View source version on businesswire.com: http://www.businesswire.com/news/home/20180130006251/en/


Taxotere Chemotherapy and Hair Loss

Is Taxotere Linked to Permanent Hair Loss and Baldness?

For more than 20 years, at Bauman Medical we’ve treated men and women who have suffered from hair loss due to hereditary conditions, illness, injury, trauma as well as medications such as chemotherapy. While all these hair loss conditions are different, what they have in common is when someone loses their hair, we know it can have significant effects on their self-esteem, self-confidence and psychological well-being. We all know that hair is important for self-expression. Our hair is a reflection of how we view ourselves and important for how others perceive us. Hair is a sign of beauty, health and youth that is recognizable from across the room. When hair is lost, whether it be a little or a lot, it can have deep and long lasting psychological effects.

Chemotherapy and Hair Loss

The psychological effects of hair loss often surprise many people and may even prevent cancer patients from seeking the proper lifesaving treatment. Recently, well-known Rolling Stone guitarist Ronnie Wood declined chemotherapy for his lung cancer, not because he didn’t think it wouldn’t work, but because he didn’t want to lose his hair!

Thankfully for most cancer patients who receive chemotherapy, their hair returns to its normal state after the drug has been withdrawn. For others, changes in texture, color, curl and coverage are lingering problems that can be dealt with in terms of styling, hair replacement, and-or doctor-directed hair regrowth treatment options, if desired. However, when hair growth does not return after chemotherapy, especially when this happens unexpectedly, permanent baldness becomes more of a significant, long-term disfiguring burden to bear.

Breast Cancer, Taxotere and Hair Loss

It has been reported that more than 1,600 breast cancer survivors treated with Taoxtere or docataxel (Sanofi-Aventis) have experienced alopecia or permanent baldness with little to no hair regrowth after stopping the drug. From our Taxotere hair loss patients we’ve learned that this unexpected hair loss situation is a continuous and unwelcome reminder of the disease they worked so hard to defeat. The impact of this type of unexpected long-term hair loss cannot be underestimated and our hearts are heavy whenever these brave survivors seek our help.

Years into their remission, and even though they’re feeling physically well, these survivors are still treated as “sick” by those unfamiliar with their condition. They avoid family photos for years and must answer questions from their kids about why their mom didn’t get her hair back and others with a similar condition did. It can affect their personal life as well as their professional one–where in today’s job market, your professional image and first impression matter.

Should You Be Grateful Chemo Saved Your Life?

The now well-known story of Ami Dodson, a frustrated breast cancer survivor who is now living with chemo-induced alopecia said, “I should not be permanently disfigured.” She goes on to describe that she gets told all the time, “‘Well, you’re not dead. Shouldn’t you be grateful the chemo saved your life?’ No, I should be alive and also have hair. Disfigurement is not something we should accept as something that’s part for the course.” It should be noted that Dodson has gone on to file a lawsuit against Sanofi-Aventis regarding her permanent hair loss which she believes is related to her chemotherapy.

And Dodson, now in her 40’s, is not alone in her frustration. Her story is similar to countless others who have turned to Dr. Alan Bauman and Bauman Medical for help. When Dodson was diagnosed with aggressive breast cancer in 2010 at age 35, doctors used Taxotere (docataxel) to treat her cancer. Later, when her hair did not return or regrow, she was diagnosed with permanent chemo-induced alopecia for which there is currently no known cure.

Taxotere and Chemo-induced Alopecia

At Bauman Medical, we’ve been seeing a significant increase in chemo-induced alopecia cases over the years. These brave survivors are healthy and certainly happy to be in remission. What they are not so happy about is the permanent hair loss that they deal with daily. The traditional wigs and weaves are uncomfortable, itchy and not particularly suited for an active lifestyle–especially here in Florida and across the United States. They also don’t like the idea of having to shave what little hair they have.

CNC: Breakthrough 3D-Printed Hair Replacement Changes Lives

The good news is that new hair replacement technology recently brought to the United States from Bologna, Italy is an excellent solution. The new “CNC” Hair Prosthesis by Cesare Ragazzi Laboratories is created with a combination of 3D-printing and old-world craftsmanship. Once the scalp mould and template is sent to Cesare Ragazzi in Bologna, the 39-step / 240+ man-hour process is begun. The breathable, dermato-compatible “second skin” is matched with proper texture and complexion color. Then, up to 100,000 unprocessed human hair strands are meticulously blended and matched to the patient’s specifications.  These hair strands are delicately sewn strand-by-strand into the “second skin” of the prosthetic’s medical-grade polymeric base with an incredible attention to artistry and detail–the angle, orientation and position of each hair is designed to be virtually identical to mother nature’s patterns.

When the CNC Hair Prosthesis for chemo is applied to the woman with severe chemotherapy hair loss and styled, the end result is a hair replacement system like no other in terms of naturalness, beauty and durability and unmatched in the freedom of lifestyle provided. Swim, shampoo, shower, dance, curl and style… all as if it was your own natural head of hair.

Learn more about the Cesare Ragazzi CNC hair and scalp prosthetic hair replacement system from Dr. Bauman—the first physician in North America to offer this life-changing solution for permanent chemo-induced alopecia which is helping cancer survivors once again live their lives with a full head of hair. For more information on the CNC Italian Hair System, start here: www.baumanmedical.com/schedule-consultation


Hair Loss Expert Dr. Alan Bauman to Present at Premiere Orlando, the Beauty Industry's Most Important Show

Premiere orlando dralanbauman2.001

The epicenter of the beauty industry is Premiere Orlando--International Beauty Event, happening this weekend. With more than 57,000 attendees from all 50 states and over 44 countries, 800 exhibitors across a 7-acre exhibit floor, this event has the reputation as the Industry's Most Important Show for all things salon and spa. Top celebrity stylists will debut the latest hairstyle trends on the Main Stage and the most-followed and most influential artists, manufacturers and professionals will be together under one roof. This year for the first time, there will be an entire educational area dedicated exclusively to Hair Loss and Trichology... which is great news for the tens of millions of men and women in the U.S. suffering from hair thinning and hair loss and their stylists who want to help.  It is also one of the reasons we are excited to attend this year as well as present scientific information on my specialized area of expertise to the beauty community.  Through our participation in events such as Hair+ Summit and our own HairCoach Certification program for medical and beauty professionals, we have already educated hundreds of licensed professionals. 

In collaboration with Hair+Summit by Modern Salon and HAIR.University, I will be presenting "Understanding Hair Loss & Hair Restoration: A Medical Perspective" on Monday, June 5th 11am-12:15pm W309A at Premiere Orlando this year. If you plan to be at #PremiereOrlando or it's co-located show #PremiereDAYSPA, let's connect! It should be a fantastic event... I hope to see you there!

Licensed Medical and Beauty Professionals can register for education and hand-on training in trichology, hair loss analysis, hair restoration treatments, PRP training, hair transplant and other hair replacement options at HairCoach.net. Limited seating is available for next class, so register early!

 


Replicel releases safety, efficacy data on RCH-01 DSCC regenerative cell therapy for baldness, thinning hair.

According to data released by Replicel on March 14, 2017, "The five-year trial data set has confirmed the complete safety profile of a high-dose of dermal sheath cup cells (DSCC) for patients with pattern baldness due to androgenetic alopecia." 

DSCC therapy is the keystone technology for Replicel's RCH-01 product. Replicel reports that the first-in-human data on long-term safety endpoints for RCH-01 successfully met it's endpoints as they move forward toward further research, development and commercialization of the hair loss product in collaboration with Japanese company Shiseido. 

According to Replicel, histological examination of the injection sites via biopsies at 6, 12, 24 and 60 months after treatment on 19 patients revealed no significant pathology (tumor, granuloma, foreign body formation, etc.)  

 

 

In addition, efficacy data--while not statistically significant--revealed that there was a overall stabilization of hair loss in all participants as well as up to a 21% improvement in hair density in a top tier responder (average 4.2% increase in hair density overall). 

Replicel Chief Scientific Officer, Dr. Kevin McElwee, alluded to further research focusing on designing optimal cell number (dosage) and injection frequency (timing) to optimize peak efficacy in terms of increased hair density.  From his statements, it appears that smaller cell doses and more frequent treatment sessions may be used to achieve a superior effect in terms of increasing hair regrowth. 

“In summary,” stated RepliCel’s President and CEO, R. Lee Buckler, “we are very pleased with the results of this first-in-human study and are excited to move this product forward into the next phases of development.”

At Bauman Medical in Boca Raton, FL we are actively watching this--and other--continuing research in the field of cell therapy for hair regrowth in androgenetic alopecia (pattern baldness in men and women).  We are hoping to see the hair measurements of the hair regrowth performed with the HairCheck device which can be used to measure results from hair loss treatments such as PRP with Extracellular Matrix, SVF, MSCs, adipose stem cells or other cell therapy, compounded Formula 82M minoxidil, topical finasteride, laser therapy, hair transplantation and more. 

 

 


Dr. Alan J. Bauman Hair Loss Expert Interview w/ Dr. Barry Lycka - Inside Cosmetic Surgery 03-13-2017

RADIO INTERVIEW - SHOW TRANSCRIPT 

13 March 2017 Inside Cosmetic Surgery Today on WebTalkRadio.net Interview with Dr Barry Lycka & Dr Alan Bauman

Dr Barry Lycka Cosmetic Dermatologist from Edmonton, Alberta is talking today with

Dr Alan J Bauman, ABHRS, FISHRS Board-Certified hair transplant surgeon from Boca Raton, Florida.

This is your number one internet radio show on cosmetic surgery, in the world! We get over 8000 downloads per week, because this show is designed for those who want the newest and best information about cosmetic surgery, and of course we have the best expert doctors as our guests. Thank you to all our listeners who have made that growth possible. If you have any topics you would like us to feature, please email Dr Lycka directly on [email protected].

Today Dr Lycka is talking with very popular repeat guest, Dr Alan Bauman, from his practice in Boca Raton, Florida. Dr Bauman always shares with us the very latest and best techniques & technologies for looking after our hair and dealing with the devastating problem of hair loss. He is one of the most knowledgeable people in the world when it comes to hair loss treatment. Both men AND women suffer hair loss for a variety of reasons. It is such a common problem and yet it is such a debilitating problem too. People hate to have thinning hair and a bald head.

Welcome, Dr Bauman!

Thank you, Barry it’s great to be back with you.

What percentage of men get hair loss, Alan?

It can start any time after puberty so 20% of men in their 20s, 30% of men in their 30s, 40% of men in their 40s and it just keeps going upwards from there. So over half the men over the age of 50 are going to have some visible signs of hair loss. And of course, many don’t want to lose their hair! They want to keep looking young and feeling great!

If a man has hair loss, is it always due to their genes & hereditary factors or are there different reasons for hair loss as well?

There are lots of types of hair loss. 98% of men who come into the clinic have hereditary male pattern hair loss. There are sometimes exceptions. Dr Bauman had an interesting case today, an unusual medical condition that obliterates the hair follicles and sometimes mimics what male pattern hair loss looks like. But the majority will have the tendency to weak, miniaturized hair, and eventually some degree of baldness and hair loss.

Let’s start at the beginning. A man is starting to lose his hair what are the signs that he has male pattern alopecia?

Typically, it starts with a recession of the frontal hairline. The forehead starts getting bigger as the hair recedes at the front and sides. Also, there can be loss of density and fullness and coverage in the crown area too. These are the 2 places that we typically see male pattern hair loss start. It can progress onwards from there. As the hair follicles miniaturize, and weaken over time, then there is the loss of more and more density, more loss of caliber of hair, and loss of coverage even over the entire top of the scalp. And of course, it spares the hair follicles around the sides and back so you typically see that ‘monks ring’ of hair around the sides and the back.

Of course, some people consider hair loss as sexy – not everyone agrees with that! But the good news is that the hair follicles are being miniaturized – they are NOT going away. That is good news, isn’t it?

Yes, it is. If action is taken early enough then you have time. You can interrupt the miniaturization process and regrow those hairs, thicker, fuller and healthier. Once a follicle is dead and gone then you must do something more aggressive to restore hair growth.

Let’s start with a man starting to lose hair. What can they do themselves without visiting a doctor – are there any over the counter products that can help?

There certainly some over the counter treatments that are FDA approved, such as minoxidil products. There are also over the counter, consumer, low level laser devices available. BUT, even though they are FDA approved proven to grow hair sometimes patients can have problems because they don’t know exactly how to use the treatments or even what to expect. Even if they are doing the treatments 100% correctly they don’t know what to expect in terms of a result.

The most important thing for listeners to understand is that if they are experiencing some hair loss they should seek expert advice, find a hair restoration physician. They have to find someone who can measure and monitor their hair situation and really diagnose exactly what is happening. Male pattern hair loss may be visible from across the room but there may be areas of weak or miniaturized hair that are not yet dead and gone, or areas where too much density has already been lost and applying a topical treatment from over the counter is just not going to get the job done.

That is such an important point. The first thing that anyone who is suffering a dermatological problem, and that includes hair loss, needs to do is get a proper diagnosis. Without a diagnosis, nothing can be treated properly. So back to the example quoted earlier, that person had a rare scarring process going on, causing the hair loss. That person had already been to a dermatologist who said it was just male pattern baldness, and that was that. But on closer inspection it was a totally different problem of scarring alopecia, that was mimicking male pattern baldness.

What tests can be done to help diagnose what the hair loss is and what type it is.

The first thing that happens at Dr Bauman’s clinic is a detailed evaluation. What is happening, how quickly, are there risk factors, medical factors, diet, illness, things that affect the body’s metabolism, medication. All these contribute to the whole picture of the hair loss situation.

Then what does it look like, is it receding, balding at the crown? Measurements are taken with a Hair Check Trichometer. It is a tool which measures the numbers of hairs and how thick they are in different areas of the scalp. The permanent zone (that are where your head hits the pillow first) is compared against the crown, the frontal, temples. These measurements are very important over time. They have established a base line against which it is possible to track the response to different treatments.

Then the second thing will be to look at the scalp under a microscope. And amazingly we have something we can add to an iPhone to do this, and look directly at the scalp with high powered magnification. This helps determine the density. How any hairs are there, are they good, thick and healthy? Is it a forest of oak or a few blades of grass!

These tests help us determine how the hair loss has progressed and predict the expected response to various treatments.

Age also affects the different risks for patients. For example, an older man sitting at home on a diet of tea and toast might wonder why his hair is falling out. Younger men using supplements to help improve physique and sports performance that can also cause hair loss. Creatine pills for example have been shown to cause hair loss, with aggressively miniaturized hair follicles.

There is a huge movement in regenerative medicine and anti-aging to do hormone replacement therapy and men and women can be on testosterone which can be converted in the body into dihydrotestosterone which we know, for men, is the trigger for male pattern hair loss. That is therefore a big risk factor. So, steroids, and hormone replacement therapy under the care of a general practitioner, can affect the hair follicle cycling.

Even poor sleep habits can cause excessive hair shedding.

So, moving on to hair loss in women.

What percentage of women have hair loss?

This also varies by age, and around 50% of women aged 50 and older will have some visible signs of hair loss. The feel decreased volume, maybe less coverage on their scalp. In women, hair loss can happen any time after puberty, just like in men. It is typically subtler, and is not usually easily recognized from across the room as in men.

Female pattern hair loss looks different.

Is there always a strong family link with this?

Yes, just as with men, there is a strong genetic link, but women’s hair is more sensitive to other things such as illness, hormone imbalance, disrupted sleep/wake cycles, stress – even than men.

There are also plenty of non-genetic hair loss such as auto-immune conditions, so once again we need to get the ladies in for a diagnosis and look for the risk factors and issues than can be contributing to the hair loss situation. Problems could be in the form of excessive shedding, receding hair line, and usually a loss of volume. They notice that they can’t do the same hairstyles they could when they were younger.

Again, what are some of the simple tests that you do, and what patterns do you see in female hair loss situations.

Once again, we will be looking at the scalp and going through the timescale of how and when the hair loss has occurred. Female hair loss usually does not recede the hairline but will be a loss of density and caliber. It usually spares the hair around the back of the scalp and around the sides -they remain unaffected. There will be the detailed medical history, blood tests, and if it is unclear what is going on at the scalp then maybe a biopsy will be suggested. But, most of the time, the diagnosis in the clinic will be made by the medical history and the physical examination.

When patients visit Dr Bauman’s practice, it is not an automatic biopsy procedure which is often offered in a dermatology office, there will be an hour-long investigation to see exactly what is happening with their health and to try and get to the bottom of the situation. The risks are identified – medications can be a very strong trigger for female pattern hair loss.

OK. So, we have got to the point where, for both men & women, we know they have hair loss, male pattern hair loss or female pattern hair loss and what is causing it.

What are the first steps in treating it?

First steps are to go through the different options available to treat the hair loss.

For men, the oral therapies are the first line approach – Finasteride, is the first line of approach. For women, it might be a topical medication, or a laser light device. These are the basics. Even at this point many men, even though they understand that Finasteride has a strong influence in preserving, protecting, and enhancing their own hair, they may want to try something that is non-pharmaceutical, and shy away from the typical FDA approved oral treatments. This means Dr Bauman goes through the whole gamut of therapies across the board that are available. Many people want to avoid the pharmaceutical treatments these days.

Typically, if we know it is androgenetic alopecia, then Finasteride (Propecia) is the medication which reduces the DHT and that works ‘pretty darn good’ in 90% of the time, and patients look the same or better in the long run, for men. In women if a topical medication is going to be used, then Dr Bauman will typically prescribe a compounded version of Minoxidil, like Formula 82M as opposed to the Rogaine that is available over the counter. Rogaine tends to be more greasy and gooey and not all that strong. The compounded medications, like 82M, are stronger, give a little bit more ‘oomph’ to the treatment, and are a lot easier to use. Unlike the oral medications which is taken once a day, topical medications must be used twice a day to be truly effective. Both men and women can use the topical medications.

Laser light therapy devices can be used for both men and women. There are devices to take home – patients don’t have to go to the clinic 3 times a week for clinic treatments. They take the Laser Cap device home and use it 30 minutes every other day, to get the best results.

If you want to stay away from chemical therapies then you are looking at laser light devices, and maybe even PRP treatments.

PRP – Platelet Rich Plasma - is a new modality that is used in regenerative medicine. We harvest and exploit the platelets that regenerate tissue.

When you are talking about laser therapy, are you talking about the red lasers that are found in some of these cap devices?

Yes. Laser therapy for hair regrowth is in the red wavelength, it is visible red light but it is the laser diodes that give the best results, NOT LED’s. There are laser caps – you wear them on your head, they are hands free, cordless and rechargeable, and they are powerful. They are more effective and easier to use than the devices we used to have in the clinic!

Are there any better devices? It’s easy to get lost when searching for ‘laser for hair loss’ everybody seems to be trying to sell one!

Yes, there is a huge variety of different lasers ‘out there’ and many are FDA cleared for hair regrowth, so they have been proven to the FDA that they are effective but you need to look for the laser with the highest number of LASER diodes – not LED’s. They must be laser light – those are the diodes that are the most effective in re-growing hair. Importantly, to get some regeneration, the hair follicles must not be dead and gone. They can be weak but not dead. But that is true of just about any other therapy as well. There must be a hair follicle there for it to grow hair.

For a laser cap device, you should get one with about 220 diodes. There are some coming out with 300 diodes which are the latest and greatest ones. They must cover the whole scalp and deliver enough energy to get some good results. And we must measure to check the progress of results!

Back to oral medications – do you use oral medications in women too?

Post menopause we can use the hormone modulating treatments because there is no risk to a pregnant woman or developing fetus. But to determine if a woman should take Finasteride, given that she is post-menopausal, a genetic test called “HairDX” is taken first to determine if she is androgen sensitive. Not all women are androgen sensitive. We can determine who is most likely to respond to the Finasteride / androgen modulating treatments. If a woman is androgen sensitive, then it is possible to prescribe the Finasteride for post-menopausal women. Dr Bauman sees some great results with it.

As we come towards the end of our time today, please can you summarize for us what we have talked about today?

The most important thing for any man or woman who is experiencing hair loss and doesn’t like it, Dr Bauman’s advice is to get a medical evaluation by a board-certified hair restoration physician. The ABHRS is the American Board of Hair Restoration Surgery. It is also an international board and there are only a small number of physicians in the world who have achieved that board certification. When you have the evaluation, make sure you get a complete medical history, and do have evaluations such as the HairCheck measurements, and the HairCam microscope photos of the scalp and that they are recorded in your medical records. Ask for a copy of those.

Then get started on some effective treatments. Oral therapies – primarily for men;
Topical therapies – for men and women;
Laser Light devices- physician prescribed like LaserCap

PRP Platelet Rich Plasma – we didn’t talk too much about that but it’s an autologous injectable no-downtime hair re-growth treatment done over a lunch-hour that stimulates hair growth. It can work for both men and women in the early stages for up to two years.

You really need to try and keep your existing hair. If you don’t keep what you have then you are going to need some degree of FUE transplantation to fill in those gaps.

The simple advice is ‘the earlier the better’. Anyone listening who is suffering from hair loss, and not currently considering any form of treatment, then the time really is now to get the best results.

The earlier treatment is started, then the better the results are over the long run. If you wait until too many hair follicles are damaged or dead, then the treatments become more aggressive and more invasive as you go. We have great minimally invasive technology and techniques these days, to restore your own living and growing hair. In the early stage of the game patients need to take some positive action, and seek out therapy from well-trained and experienced hair restoration physicians who are trained in the medical management of hair loss.

Sadly, in the USA, most dermatologists don’t have time to do a hair loss consultation so there is a complete new sub-specialty (only about 15 to 20 years old) board certified hair restoration physician. Those physicians exclusively dedicate their practice to the treatment of hair loss and hair re-growth.

How can listeners access Dr Bauman’s specialist service?

Thanks to the power of the internet, via Dr Bauman’s website, patients can initiate a long-distance consultation, upload photos, schedule a phone call – or do it through Skype, or Facetime - and it’s almost as good as being at the office. Obviously Dr Bauman can’t do the measurements or look with the microscope, (although he is working on that!) He however can at least make a start on understanding exactly what is going on. Dr Bauman also certifies HairCoaches, so there may be someone local to them who the patient can be referred to at a hair center who can take the measurements – HairCheck and HairCam evaluation with the microscope. There are over 150 Certified HairCoaches ‘out there’, many of them international, who have been trained by Dr Bauman to help him diagnose and treat hair loss. Simply click Start Consultation.

Or of course, you can visit Dr Bauman’s facility in South Florida, Boca Raton. He has a new building completely dedicated to the treatment of hair loss and hair transplant procedures.

Thank you once again Alan for spending time educating our listeners about hair loss. Dr Lycka loves to do this show and provide real information to the listeners.

Thank you, Barry, for being such a gracious host. Dr Bauman knows that many people listen to this podcast from around the world, and say to him ‘I heard you on Dr Lycka’s show, and the information really helped me get started dealing with my hair loss.’

 

Contact details for Dr Alan Bauman:

Dr. Alan J. Bauman, M.D. – ABHRS Board Certified Hair Restoration Physician

Telephone: Boca Raton: (561) 394 0024

https://www.baumanmedical.com/